TB-500 Peptide – 5mg

TB-500 is the synthetic version of Thymosin Beta-4, a naturally occurring regenerative peptide found in nearly all human and animal cells. It is a primary regulator of actin, a key protein involved in cell structure, movement, and repair. TB-500 has been investigated for its role in promoting healing, reducing inflammation, and supporting cellular regeneration across various tissue types.

Overview

TB-500’s mechanism of action involves upregulating actin to promote cell migration, differentiation, and proliferation, particularly in endothelial and keratinocyte cells. This action is believed to accelerate wound healing, support angiogenesis (the formation of new blood vessels), and modulate inflammatory cytokine expression.

Due to its systemic and localized effects, TB-500 is a subject of research in models of musculoskeletal injury, cardiovascular repair, dermal wound healing, and neuroprotection. Unlike growth factors, its primary role is not to stimulate cell growth but to facilitate the foundational processes of tissue repair and remodeling.

Chemical Makeup

• Molecular Formula: C212H350N56O78S
• Molecular Weight: 4963.5 g/mol
• Amino Acid Sequence: Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser
• Other Known Titles: Thymosin Beta-4

Research and Clinical Studies

Wound Healing and Tissue Repair

Preclinical studies have shown that TB-500 accelerates dermal, corneal, and cardiac wound healing. It promotes the migration of stem/progenitor cells to injury sites and enhances collagen deposition and re-epithelialization.

Cardioprotection

In animal models of myocardial infarction, TB-500 was found to reduce infarct size, improve cardiac function, and promote the survival of cardiomyocytes by activating pro-survival signaling pathways.

Anti-Inflammatory Effects

TB-500 has been shown to reduce inflammation by downregulating key inflammatory cytokines like TNF-α and promoting a shift towards a pro-resolving cellular environment.

Musculoskeletal and Ligament Injury

Research indicates that TB-500 can accelerate the healing of injured muscles, tendons, and ligaments by promoting actin upregulation and cell migration, leading to faster functional recovery in animal models.

Neuroprotection

Studies suggest that TB-500 may have neuroprotective and neurorestorative effects, promoting axonal and synaptic remodeling and reducing inflammation in models of neurological injury.

TB-500 peptide is available for research and laboratory purposes only. Not for human consumption.

References

1. Goldstein AL, et al. Thymosin beta4: a new molecular target for anticancer therapy. Expert Opin Biol Ther. 2009;9(10):1317-1324. https://pubmed.ncbi.nlm.nih.gov/19698075/
2. Philp D, et al. Thymosin beta4 and wound healing. Expert Opin Biol Ther. 2010;10(9):1317-1326. https://pubmed.ncbi.nlm.nih.gov/20649451/
3. Bock-Marquette I, et al. Thymosin beta4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair. Nature. 2004;432(7016):466-472. https://pubmed.ncbi.nlm.nih.gov/15565147/
4. Crockford D, et al. Thymosin beta4 salvages ischaemic cardiac tissue. Expert Opin Biol Ther. 2010;10(4):595-599. https://pubmed.ncbi.nlm.nih.gov/20170425/
5. Sosne G, et al. Thymosin beta 4 promotes corneal wound healing and decreases inflammation in vivo and in vitro. Invest Ophthalmol Vis Sci. 2002;43(8):2546-2551. https://pubmed.ncbi.nlm.nih.gov/12147585/
6. Tsunekawa K, et al. Thymosin Beta-4 Accelerates Murine Muscle and Tendon Healing. J Orthop Res. 2017;35(10):2347-2354. https://pubmed.ncbi.nlm.nih.gov/28432863/
7. Chopp M, et al. Thymosin β4 as a restorative/neuroprotective agent for stroke. Expert Opin Investig Drugs. 2012;21(3):329-339. https://pubmed.ncbi.nlm.nih.gov/22239642/